A ONCE-MONTHLY* TREATMENT FOR SCHIZOPHRENIA IN ADULTS

*You should continue to take your current antipsychotic medication for 2 weeks after your first treatment with ABILIFY MAINTENA.

How ABILIFY MAINTENA may help

Treating schizophrenia is an ongoing process, and your treatment plan will generally include medicine, counseling, and day-to-day support. Once-monthly ABILIFY MAINTENA helps you avoid the need to take a daily oral medication for schizophrenia.

You should continue to take your current antipsychotic medication for 2 weeks after your first treatment with ABILIFY MAINTENA.

ABILIFY MAINTENA is an injection that's given by a member of your treatment team 1 time every month, after your initial dose.

No medication can guarantee that you won't miss a dose. However, once you've received the once-monthly injection, the medicine is in your body being gradually released for a month at a time.

Improving symptoms

ABILIFY MAINTENA has been shown to improve schizophrenia symptoms in patients who have experienced a relapse. In fact, patients given ABILIFY MAINTENA had improved symptoms in as soon as one week. 

A relapse was defined as clinical worsening, psychiatric hospitalization, increased risk of suicide, or violent behavior.

In a 12-week trial of 339 acutely relapsed patients with schizophrenia, ABILIFY MAINTENA was superior to placebo in improving schizophrenia symptoms.

Remaining relapse-free longer

ABILIFY MAINTENA helps people with schizophrenia remain relapse-free longer. Relapse was defined as a return of schizophrenia symptoms.

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In a 1-year clinical study that measured symptom control in 403 patients with schizophrenia, people treated with ABILIFY MAINTENA remained relapse-free significantly longer than those on placebo.

SELECT IMPORTANT SAFETY INFORMATION

Increased risk of stroke and ministroke has been reported in clinical studies with oral aripiprazole of elderly people with dementia-related psychosis and can lead to death.

What are the most common side effects of ABILIFY MAINTENA?

The most common side effects from a 12-week study of ABILIFY MAINTENA were:

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Blue scale icon

Weight gain
17% of people on ABILIFY MAINTENA
7% of people on placebo

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Syringe needle icon

Injection site pain
5% of people on ABILIFY MAINTENA
1% of people on placebo

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Restless person icon

Inner sense of restlessness (feeling like you need to move)
11% of people on ABILIFY MAINTENA
4% of people on placebo

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Sleepy emoji icon

Sleepiness (sedation)
5% of people on ABILIFY MAINTENA
1% of people on placebo

These are not all the possible side effects of ABILIFY MAINTENA.

Getting started with ABILIFY MAINTENA

Read the MEDICATION GUIDE before receiving ABILIFY MAINTENA. There may be new information. Remember it does not take the place of talking to your doctor about schizophrenia or your treatment.

Before starting treatment with ABILIFY MAINTENA, it's important to talk with your healthcare provider about medications you’ve been prescribed, relapses you've experienced in the past year, and any side effects you may have had with your current medication.

Have you already taken the pill form of aripiprazole?

  • If you have taken the pill form, be sure to tell your healthcare provider. This information will help them figure out how much medicine your body will be able to tolerate when you start ABILIFY MAINTENA.
  • If you haven't taken the pill form, tell your healthcare provider. You will be asked to take the pill form for 2 weeks before getting your first injection of ABILIFY MAINTENA, so your healthcare provider can see how well your body tolerates the medicine.

Important things to remember about your treatment

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Discussion Icon

Talk to your healthcare provider
Remember to follow your ABILIFY MAINTENA treatment schedule exactly as your healthcare provider tells you to. Your healthcare provider can tell you if it is safe to take ABILIFY MAINTENA with your other medicines. Do not start or stop any medicines while taking ABILIFY MAINTENA without talking to your healthcare provider first.

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pill icon

Take your current treatment
You should continue to take your current schizophrenia treatment for two weeks after your first treatment. This allows the levels of medicine in your body to stay consistent.

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Syringe needle icon

Receiving your injection
You will receive your medicine in the shoulder or buttock, which may cause a little pain. About 5% of people reported feeling injection pain.

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Reminder with bell icon

Don't miss a dose
If you miss a dose for some reason, call your healthcare provider right away to discuss what you should do next. Following your treatment plan can help keep your relapses under control. You and your healthcare provider will determine how much medicine your body can tolerate. Mark your injection date on your calendar to help you remember when your next injection is.

ABILIFY MAINTENA and other medicines may affect each other causing possible serious side effects. ABILIFY MAINTENA may affect the way other medicines work, and other medicines may affect how ABILIFY MAINTENA works.

Where to get ABILIFY MAINTENA

There are several ways to receive your ABILIFY MAINTENA injections—your healthcare provider may give you the injection, or there are Local Care Centers (LCC) also available.

Learn More About Local Care Centers

Save on ABILIFY MAINTENA*

ABILIFY MAINTENA Savings Card Sample

You may be eligible to start saving on your ABILIFY MAINTENA prescription by taking this card to your next injection appointment.*

Eligible patients may pay as little as $10 per 30-day calendar month with an annual maximum benefit of $8,000 and monthly $1,400 maximum. Presumes only 1 prescription filled per calendar month.

Please confirm that you are 18 years of age and commercially insured

*Conditions apply. Click to view.

INDICATIONS and IMPORTANT SAFETY INFORMATION for ABILIFY MAINTENA® (aripiprazole)

IMPORTANT SAFETY INFORMATION and INDICATIONS for ABILIFY MAINTENA® (aripiprazole)
IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION

Elderly people with dementia-related psychosis are at increased risk of death when treated with antipsychotic medicines including ABILIFY MAINTENA. ABILIFY MAINTENA is not for the treatment of people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).

Do not receive ABILIFY MAINTENA if you are allergic to aripiprazole or any of the ingredients in ABILIFY MAINTENA. Allergic reactions to aripiprazole have ranged from rash, hives and itching to anaphylaxis, which may include difficulty breathing, tightness in the chest, and swelling of the mouth, face, lips, or tongue.

ABILIFY MAINTENA may cause serious side effects including:

  • Increased risk of stroke and ministroke has been reported in clinical studies with oral aripiprazole of elderly people with dementia-related psychosis and can lead to death.
  • Neuroleptic malignant syndrome (NMS), a serious condition that can lead to death. Call your healthcare provider or go to the nearest emergency room right away if you have some or all of the following symptoms of NMS: high fever, stiff muscles, confusion, sweating, or changes in pulse, heart rate, and blood pressure.
  • Uncontrolled body movements (tardive dyskinesia). ABILIFY MAINTENA may cause movements that you cannot control in your face, tongue, or other body parts. Tardive dyskinesia may not go away, even if you stop receiving ABILIFY MAINTENA. Tardive dyskinesia may also start after you stop receiving ABILIFY MAINTENA.
  • Problems with your metabolism such as:
    • High blood sugar (hyperglycemia): Increases in blood sugar can happen in some people who receive ABILIFY MAINTENA. Extremely high blood sugar can lead to coma or death. If you have diabetes or risk factors for diabetes (such as being overweight or a family history of diabetes), your healthcare provider should check your blood sugar before you start receiving ABILIFY MAINTENA and during your treatment.

    Call your healthcare provider if you have any of these symptoms of high blood sugar while receiving ABILIFY MAINTENA:

  • feel very thirsty

  • need to urinate more than usual

  • feel very hungry

  • feel weak or tired

  • feel sick to your stomach

  • feel confused, or your breath smells fruity

  • Increased fat levels (cholesterol and triglycerides) in your blood.
  • Weight gain. You and your healthcare provider should check your weight regularly.
  • Unusual urges. Some people receiving ABILIFY MAINTENA have had unusual urges such as gambling, binge eating or eating that you cannot control (compulsive), compulsive shopping, and sexual urges.

    If you or your family members notice that you are having unusual urges or behaviors, talk to your healthcare provider.

  • Decreased blood pressure (orthostatic hypotension). You may feel lightheaded or faint when you rise too quickly from a sitting or lying position.
  • Low white blood cell count
  • Seizures (convulsions)
  • Problems controlling your body temperature so that you feel too warm. Do not become too hot or dehydrated while you receive ABILIFY MAINTENA. Do not exercise too much. In hot weather, stay inside in a cool place if possible. Stay out of the sun. Do not wear too much clothing or heavy clothing. Drink plenty of water.
  • Difficulty swallowing

Do not drive, operate machinery, or do other dangerous activities until you know how ABILIFY MAINTENA affects you. ABILIFY MAINTENA may make you feel drowsy.

Do not drink alcohol while you receive ABILIFY MAINTENA.

Before receiving ABILIFY MAINTENA, tell your healthcare provider about all your medical conditions, including if you:

  • have never taken aripiprazole before

  • have diabetes or high blood sugar or a family history of diabetes or high blood sugar. Your healthcare provider should check your blood sugar before you start receiving ABILIFY MAINTENA and during your treatment.

  • have or had seizures (convulsions)

  • have or had low or high blood pressure

  • have or had heart problems or a stroke

  • have or had a low white blood cell count

  • have problems that may affect you receiving an injection in your arm or buttocks

  • are pregnant or plan to become pregnant. It is not known if ABILIFY MAINTENA will harm your unborn baby. If you become pregnant while receiving ABILIFY MAINTENA, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics. You can register by calling 1-866-961-2388 or go to http://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/

  • are breastfeeding or plan to breastfeed. ABILIFY MAINTENA can pass into your milk and may harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive ABILIFY MAINTENA.

Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.

ABILIFY MAINTENA and other medicines may affect each other causing possible serious side effects. Do not start or stop any medicines during treatment with ABILIFY MAINTENA without talking to your healthcare provider first.

The most common side effects of ABILIFY MAINTENA include: weight gain, inner sense of restlessness such as feeling like you need to move (akathisia), injection site pain, or sleepiness (sedation).

It is important to contact your healthcare provider if you experience prolonged, abnormal muscle spasms or contractions, which may be signs of a condition called dystonia.

These are not all the possible side effects of ABILIFY MAINTENA.

If you have any questions about your health or medicines, talk to your healthcare provider.

You are encouraged to report side effects of ABILIFY MAINTENA (aripiprazole). Please contact Otsuka America Pharmaceutical, Inc. at 1-800-438-9927 or FDA at 1-800-FDA-1088 (www.fda.gov/medwatch).

INDICATIONS

ABILIFY MAINTENA® (aripiprazole) is a prescription medicine given by injection by a healthcare professional for:

  • treatment of schizophrenia in adults
  • maintenance treatment of bipolar I disorder in adults

It is not known if ABILIFY MAINTENA is safe and effective in children under 18 years of age.

 

Please see FULL PRESCRIBING INFORMATION, including BOXED WARNING, and MEDICATION GUIDE.